Michael W Donnino Selected Research

Thiamine (Aneurin)

2/2022	Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness : A Nationwide Retrospective Observational Study.
11/2021	The Effect of a Single Dose of Thiamine on Oxygen Consumption in Patients Requiring Mechanical Ventilation for Acute Illness: A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial.
12/2020	Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Health-Related Quality of Life in Sepsis.
8/2020	Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
2/2020	Thiamine (vitamin B1) in septic shock: a targeted therapy.
12/2019	Ascorbic Acid, Corticosteroids and Thiamine in Sepsis (ACTS) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomised, placebo-controlled clinical trial.
10/2018	Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation.
1/2018	The Effects of Thiamine on Breast Cancer Cells.
5/2017	Thiamine as a Renal Protective Agent in Septic Shock. A Secondary Analysis of a Randomized, Double-Blind, Placebo-controlled Trial.
2/2016	Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.

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Michael W Donnino Research Topics

Disease

64	Heart Arrest (Cardiac Arrest) 01/2021 - 11/2007
20	Sepsis (Septicemia) 01/2021 - 08/2007
18	Out-of-Hospital Cardiac Arrest 01/2021 - 10/2013
17	Septic Shock (Toxic Shock Syndrome) 02/2022 - 08/2011
12	Critical Illness (Critically Ill) 02/2022 - 01/2010
10	Infections 01/2019 - 08/2007
8	Shock 01/2022 - 08/2007
7	Coma (Comas) 11/2020 - 12/2010
5	Thiamine Deficiency 02/2020 - 12/2007
5	Lactic Acidosis 03/2016 - 12/2010
4	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 02/2022 - 10/2013
4	Hypotension (Low Blood Pressure) 01/2021 - 02/2008
4	Pneumonia (Pneumonitis) 01/2021 - 07/2013
4	Wounds and Injuries (Trauma) 10/2013 - 08/2007
3	Liver Diseases (Liver Disease) 01/2021 - 12/2010
3	Neoplasms (Cancer) 01/2021 - 10/2013
3	Pulmonary Embolism 11/2020 - 09/2020
3	Ventricular Fibrillation 01/2020 - 07/2008
3	Inflammation (Inflammations) 12/2017 - 09/2014
3	Hypothermia 11/2015 - 07/2008
2	Human Influenza (Influenza) 01/2021 - 01/2019
2	Ventricular Tachycardia 01/2020 - 12/2018
2	Syncope (Fainting) 12/2019 - 12/2019
2	Stroke (Strokes) 11/2019 - 10/2019
2	AIDS-Related Complex (ARC) 11/2019 - 01/2017
2	Brain Injuries (Brain Injury) 01/2019 - 01/2016
2	Acidosis 04/2018 - 12/2007
2	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 11/2017 - 11/2014
2	Fever (Fevers) 01/2017 - 11/2014
2	Confusion (Bewilderment) 09/2016 - 08/2007
2	Respiratory Insufficiency (Respiratory Failure) 11/2012 - 10/2012
2	Bacteremia 11/2012 - 08/2012
2	Wernicke Encephalopathy (Wernicke's Encephalopathy) 12/2007 - 12/2007
1	Traumatic Brain Injuries (Traumatic Brain Injury) 02/2022
1	Alcoholism (Alcohol Abuse) 02/2022
1	Tachycardia (Tachyarrhythmias) 01/2022
1	Back Pain (Backache) 09/2021
1	Pain (Aches) 09/2021
1	Hypoxia (Hypoxemia) 01/2021
1	COVID-19 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Cardiac Arrhythmias (Arrythmia) 01/2021
1	Post-Cardiac Arrest Syndrome 11/2020
1	Clinical Deterioration 12/2019
1	Bradycardia 10/2019
1	Cytokine Release Syndrome 10/2019

Drug/Important Bio-Agent (IBA)

19	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 11/2007
16	Thiamine (Aneurin)FDA Link 02/2022 - 01/2010
8	Epinephrine (Adrenaline)FDA LinkGeneric 12/2019 - 07/2012
7	Pharmaceutical PreparationsIBA 01/2021 - 07/2015
6	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2013
6	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2020 - 02/2008
6	Anti-Bacterial Agents (Antibiotics)IBA 11/2020 - 11/2014
5	coenzyme Q10 (CoQ10)IBA 01/2021 - 08/2011
5	Ascorbic Acid (Vitamin C)FDA LinkGeneric 12/2020 - 10/2018
5	Oxidoreductases (Dehydrogenase)IBA 01/2017 - 07/2015
4	Cytochromes c (Cytochrome c)IBA 12/2020 - 05/2016
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2014
4	Pyruvic Acid (Pyruvate)IBA 01/2017 - 11/2015
3	Oxygen (Dioxygen)IBA 01/2021 - 12/2019
3	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 04/2012
2	ubiquinolIBA 01/2021 - 07/2015
2	Lidocaine (Xylocaine)FDA LinkGeneric 01/2020 - 12/2018
2	Amiodarone (Amiodarona)FDA LinkGeneric 01/2020 - 12/2018
2	Anti-Arrhythmia AgentsIBA 12/2018 - 07/2008
2	Biological ProductsIBA 10/2018 - 03/2016
2	Hydrocortisone (Cortisol)FDA LinkGeneric 10/2018 - 04/2016
2	Bicarbonates (Hydrogen Carbonate)IBA 04/2018 - 02/2014
2	AcidsIBA 01/2016 - 12/2007
2	cytidylyl-(3'-5')-cytidine (CpC)IBA 11/2014 - 02/2012
2	Indicators and Reagents (Reagents)IBA 05/2013 - 08/2012
1	esmolol (Brevibloc)FDA LinkGeneric 01/2022
1	Pain-FreeIBA 09/2021
1	Thiamine PyrophosphateIBA 02/2020
1	Anti-Anxiety Agents (Anxiolytics)IBA 12/2019
1	Narcotics (Narcotic Analgesics)IBA 12/2019
1	Immune Checkpoint InhibitorsIBA 10/2019
1	Dihydrotachysterol (AT 10)IBA 10/2019
1	NivolumabIBA 10/2019
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019
1	glutathione-independent formaldehyde dehydrogenase (formaldehyde dehydrogenase)IBA 01/2019
1	Atropine FDA LinkGeneric 01/2019
1	Interleukin-2 (IL2)IBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019
1	Interleukin-10 (Interleukin 10)IBA 01/2019

Therapy/Procedure

35	Resuscitation 01/2021 - 08/2007
18	Induced Hypothermia 01/2021 - 02/2012
16	Therapeutics 09/2021 - 03/2009
16	Cardiopulmonary Resuscitation (CPR) 01/2021 - 11/2015
6	Artificial Respiration (Mechanical Ventilation) 01/2021 - 12/2010
5	Critical Care (Surgical Intensive Care) 01/2021 - 12/2015
4	Rewarming 01/2021 - 03/2012
2	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2021 - 05/2017
2	First Aid (Aids, First) 12/2019 - 12/2019
2	Advanced Cardiac Life Support (Life Support, Advanced Cardiac) 01/2019 - 09/2016
2	Airway Management 01/2019 - 01/2014
2	Defibrillators (Defibrillator) 01/2018 - 11/2017
1	Central Venous Catheters 01/2020
1	Percutaneous Coronary Intervention 12/2019